Industrial CT Scanning and Dimensional Metrology for Prefilled Syringes, Cartridges, and Pharmaceutical Packaging Components

Pharmaceutical packaging companies need tight dimensional control—there’s no room for error when it comes to prefilled syringes, cartridges, or primary packaging systems. Precision here drives product quality, keeps manufacturing on track, and makes sure components actually fit together all the way from filling through final delivery.

If you miss the mark on those critical dimensions—think glass containers, stopper systems, needle interfaces, or entire assembled delivery devices—you can run into all kinds of trouble. Suddenly, you’re dealing with leaky seals, jams on the fill line, or devices that just don’t work right, and reliability goes out the window.Nel PreTech steps in with industrial CT scanning, dimensional inspection, and full metrology services, especially for teams that need to comply with ISO 11040-2, -4, -5, or -6. We run an ISO/IEC 17025 accredited lab. This means engineering, quality, and manufacturing teams can count on us for the measurement data they need. 

Supporting ISO 11040 Verification and Quality Programs

From early-stage development through production quality assurance, manufacturers rely on objective measurement data to evaluate critical dimensions, assembly performance, and manufacturing consistency. Nel PreTech provides industrial CT scanning and dimensional metrology services that support these efforts with accurate, actionable inspection results.
Nel PreTech supports:
  • Product development
  • Design verification
  • Process validation
  • Supplier qualification
  • Production quality assurance
  • Failure investigations
  • Continuous improvement initiatives

Glass Dimensional Analysis and Defect Characterization

A Specialized Capability for Pharmaceutical Packaging Manufacturers

Glass syringes and cartridges require more than dimensional inspection alone. Manufacturers must understand how dimensional variation, wall thickness distribution, and glass-related defects may influence assembly performance, filling operations, container integrity, and downstream device compatibility.Nel PreTech combines industrial CT scanning and precision metrology to provide a comprehensive analysis of both glass geometry and material conditions.

Internal Bore Measurement

The internal bore directly influences stopper performance, glide force, filling operations, and overall functionality.

Inspection capabilities include:

  • Internal diameter measurement
  • Bore profile analysis
  • Taper evaluation
  • Straightness assessment
  • Internal geometry verification

These measurements help manufacturers evaluate dimensional consistency across production lots and supplier sources.

Wall Thickness Distribution Analysis

Traditional inspection methods often evaluate wall thickness at only a limited number of locations.

Industrial CT scanning allows complete wall-thickness mapping throughout the entire syringe or cartridge.

This enables manufacturers to identify:

  • Thin-wall regions
  • Thickness variation
  • Material distribution trends
  • Manufacturing inconsistencies

Wall thickness distribution data is frequently used during process validation, supplier qualification, and failure investigations.

Neck and Shoulder Geometry Verification

Critical dimensional relationships often exist within the neck and shoulder regions.

Inspection capabilities include:

  • Neck diameter measurement
  • Shoulder profile evaluation
  • Transition geometry analysis
  • Closure interface verification
  • Feature location assessment

These dimensions can significantly impact assembly operations and container closure performance.

Concentricity and Alignment Analysis

Manufacturers frequently evaluate:

  • Bore concentricity
  • Neck-to-body alignment
  • Feature location relationships
  • Geometric consistency

This information is particularly valuable for cartridge systems that interface with injector platforms and automated assembly processes.

Glass Defect Characterization

In addition to dimensional conformity, manufacturers often need visibility into defects that may affect product quality and manufacturing performance.

Bubble and Void Analysis

CT scanning allows engineers to visualize and characterize internal bubbles and voids within glass structures.

Analysis may include:

  • Bubble size
  • Distribution
  • Location
  • Frequency
  • Comparative lot analysis

This information can support supplier evaluations and process investigations.

Inclusion Detection

Foreign material inclusions can occur during glass manufacturing processes.

Industrial CT scanning can assist in identifying and characterizing:

  • Unmelted particles
  • Refractory fragments
  • Material anomalies
  • Internal inclusions

Engineers can evaluate the size, location, and potential impact of these conditions.

Crack Investigation

Small cracks and fracture initiation sites may not always be visible through external inspection methods.

CT scanning provides non-destructive insight into:

  • Internal crack formation
  • Fracture propagation
  • Hidden structural damage

This capability is particularly valuable during root cause investigations and supplier quality assessments.

Dimensional Deformation Analysis

Manufacturers may encounter:

  • Ovality
  • Neck deformation
  • Warpage
  • Geometric distortion

CT-based dimensional analysis can quantify and compare these conditions against design requirements.

Components Commonly Evaluated

Prefilled Syringes

Inspection capabilities include:

  • Bore measurement
  • Wall thickness analysis
  • Needle attachment features
  • Flange geometry
  • Closure interfaces
  • Assembly verification
Glass Cartridges

Evaluate:

  • Internal diameters
  • Neck geometry
  • Shoulder profiles
  • Wall thickness
  • Sealing surfaces
  • Assembly interfaces
Elastomeric Closures

Inspect:

  • Stopper geometry
  • Interface conditions
  • Compression characteristics
  • Assembly fit
Complete Assemblies

InspectAnalyze::

  • Syringe assemblies
  • Cartridge systems
  • Closure systems
  • Integrated drug delivery devices

Industrial CT Scanning for ISO 11040 Applications

Internal Dimensional Analysis

Evaluate hidden geometries and inaccessible features without sectioning.

Assembly Verification

Inspect component relationships and interface conditions without disassembly.

CAD-to-Part Comparison

Compare manufactured components directly against CAD models.

Wall Thickness Analysis

Generate complete wall thickness maps for glass and polymer components.

Defect Characterization

Identify and analyze cracks, voids, inclusions, and manufacturing anomalies.

Dimensional Metrology Services

Critical Feature
Verification
GD&T
Inspection
First Article
Inspection
Statistical Measurement Studies
Supplier Qualification Programs
Process Validation Support

Why Pharmaceutical Manufacturers Partner with Nel PreTech

ISO/IEC 17025 Accredited Laboratory

Measurement traceability and confidence.

ZEISS METROTOM Industrial CT Systems

Advanced internal inspection and dimensional analysis.

Expertise in Pharmaceutical Packaging Inspection

Unlike many CT service providers, Nel PreTech routinely evaluates dimensional relationships, wall-thickness distribution, and internal conditions associated with pharmaceutical packaging and drug delivery systems.

Engineering-Focused Reporting

Actionable inspection data designed for engineering, quality, manufacturing, and validation teams.

Collaborative Technical Support

Direct engagement with engineers and quality professionals throughout the inspection process.

Why Pharmaceutical Manufacturers Partner with Nel PreTech

Frequently Asked Questions

Can CT scanning evaluate wall thickness throughout an entire glass syringe or cartridge?

Yes. CT scanning generates complete wall thickness maps that provide far more information than point-to-point measurements.

Can CT scanning identify bubbles and inclusions within pharmaceutical glass?

Yes. Industrial CT scanning can detect and characterize many internal glass anomalies, including bubbles, voids, inclusions, and crack-related conditions.

Can CT scanning compare dimensional variation between suppliers?

Yes. Manufacturers frequently use CT-generated dimensional data to compare supplier performance and support qualification activities.

Case Studies

Colormap of CT scan data within VG software
Challenge:

A major consumer product company struggles to develop, approve, and launch multiple high-level cavitation molds for high-volume production & global distribution.

Solution:

Computed tomography and value-add services from Nel PreTech.

Results:

Client saves $1 million in direct cost and gains $60 million in cash flow four months sooner.

The Scoop: Product development & launch expedited with industrial CT scanning of new tooling.

View Full Case Study
Industrial CT scanning services allows analysis of hidden elements
Challenge:

Major grill manufacturer reaches out with malfunctioning glow plugs.

Solution:

Industrial CT scanning (x-ray material testing) provides digital 3D x-ray images of internal components of the glow plug & finds a wire break inside the heating device.

Results:

Client is able to investigate the root cause of the glow plug failure and fix the problem.

Grillers Rejoice: Pellet grills saved by industrial CT scanning.

Read Full Case Study
Blue light scan of an automotive door handle
Challenge:

Global OEM medical device company needs help developing and launching drug delivery pumps.

Solution:

CT scanning and value-add services create a turnkey solution to give the client a competitive advantage.

Results:

20 new tools in 20 weeks.

A Medical Miracle: Drug delivery pumps developed and launched in record time with 3D scanning services.

Read the full Case Study

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